What is Leptospirosis?
Globally, Leptospirosis is a widespread, emerging public health problem.1 It is a potentially fatal illness that may occur when people come into contact with harmful germs in their environment.2 The bacteria that cause the disease, Leptospira, may be contracted through direct contact with infected animals or their habitats, along with indirect contact via the ingestion of contaminated food or water.3 While most cases are mild, causing influenza-like symptoms, some cases progress to a lethal form called Weill’s disease.4
How do people typically get Leptospirosis?
According to the World Health Organization, “Humans become infected through direct contact with the urine of infected animals or with a urine-contaminated environment. The bacteria enter the body through cuts or abrasions on the skin, or through the mucous membranes of the mouth, nose and eyes.”5
While rodents are the most common carriers, Leptospira bacteria may be found in cattle, pigs, horses, goats, dogs and wild animals.6 This means that virtually any raw, outdoor water source is vulnerable to contamination. People may contract Leptospirosis due to exposure to the bacteria during occupational or recreational activities, or due to consuming raw, untreated water sources or contaminated food.
Numbers in the US and Globally
In the United States, “It is estimated that 100-150 Leptospirosis cases are identified annually … About 50% of cases occur in Puerto Rico.”7 States with warm, humid climates experience more occurrences than those with cooler climates. Hawaii specifically posts signs to warn visitors not to be, “…exposed to fresh water ponds or streams … especially if you have open cuts or sores.”8
Globally, the National Center for Biotechnology Information (NCBI) reports:
Overall leptospirosis was estimated to cause 1.03 million cases and 58,900 deaths each year. These estimates place leptospirosis as a leading zoonotic cause of morbidity and mortality. In addition, morbidity and mortality was greatest in the poorest regions of the world and in areas where surveillance is not routinely performed.9
Certain occupations put people at higher risk of exposure to Leptospira bacteria due to interactions with animals or vulnerable environments. Examples include:
- Farm and agricultural workers
- Pet shop workers
- Sewer workers
- Meat handlers
- Military personnel10
A Note Regarding Agricultural Communities
According to the World Health Organization, “In some countries, practically the whole population is at risk as a result of high exposure to contaminated water in daily activities, e.g. working in paddies and sugarcane plantations.”11 Agricultural communities quite simply experience higher rates of infection due to being in constant contact with animals, soil, and raw water.
In the United States, the most common source of exposure is through recreational activities. According to the CDC:
The disease has also been associated with swimming, wading, kayaking, and rafting in contaminated lakes and rivers. As such, it is a recreational hazard for campers or those who participate in outdoor sports. The risk is likely greater for those who participate in these activities in tropical or temperate climates.12
Leptospira bacteria thrive in “High humidity and neutral (6.9–7.4) pH,” with “stagnant water reservoirs—bogs, shallow lakes, ponds, puddles, etc.—being the natural habitat for the bacteria.”13 As long as urine from the infected animal remains moist, or has access to a water source, Leptospira may survive.
DEVELOPING URBAN AREAS
While historically considered a rural disease, Leptospirosis, “… has disseminated from its habitual rural base to become the cause of urban epidemics in poor communities of industrialized and developing nations.”14
Climate, Rainfall and Sanitation
Cases of Leptospirosis are known to spike in poor, urban areas with tropical climates during periods of higher rainfall. The NCBI explains further, “For example, the cyclic pattern of spring and summer rains can increase the incidence of water-borne diseases; and, this annual pattern of rains can be further exacerbated by natural disasters.”15
Major outbreaks in India demonstrate potential methods of exposure:
- Contact with contaminated water due to poor drainage (via a skin abrasion or unintentional ingestion)
- Consumption of potentially contaminated food and beverages sold by street vendors
- Consumption of inadequately treated tap water or raw water sources
- Contact with infected rat populations
Flooding due to natural disasters such as monsoons or hurricanes can inundate communities with potentially contaminated water. Such scenarios typically pose three major concerns:
- Raw, standing water may contain several types of bacterial contaminants (among other concerns such as viruses, cysts and chemicals)
- Water treatment plants in low-lying areas may be compromised, spilling partially-treated sewage from pipes, open air basins and holding tanks and pumps
- Power outages and infrastructure damage may lead to tap water shortages or unreliable tap water quality
In the event of a water shortage or disruption, residents may turn to raw, outdoor sources such as lakes, rivers, or streams, which are vulnerable to Leptospira bacteria. Consuming untreated or inadequately treated raw water can put people at serious risk of infection.
Learn more about post-hurricane flooding specifically in our article, “After the Hurricane: Contaminated Flood Water Precautions.”
What are the symptoms of Leptospirosis?
Referred to by some sources as a “mimic disease,” cases of Leptospirosis can be difficult to identify. It is often confused with dengue fever, influenza, meningitis, hepatitis and other viral hemorrhagic fevers.16 According to the CDC, Leptospirosis can cause a wide range of symptoms:
- High fever
- Muscle aches
- Jaundice (yellow skin and eyes)
- Red eyes
- Abdominal pain
It is common that the illness develops after the individual can clearly connect their symptoms with exposure to a potentially contaminated source. The CDC explains, “The time between a person’s exposure to a contaminated source and becoming sick is 2 days to 4 weeks.”18
Course of the Disease
The course of the disease typically involves two phases: a septic state and immune response. The first phase generally involves the abrupt onset of fever, chills, headache, muscle aches, vomiting, or diarrhea, and lasts 3-7 days. After a one to three day period with minimal symptoms, the immune response begins and antibodies appear in the blood. Many symptoms return, and the individual may continue to be sick for days or weeks longer.
A more severe form of Leptospirosis, comprising 5-10% of cases, is known as Weill’s Disease. According to the NCBI, it… “has a fatality rate of 5-10%; and, the rate increases to 20-40% with hepatorenal involvement and jaundice.”19 (Heptorenal- involves a rapid decline in kidney function.20)
The disease involves the symptoms mentioned above, along with severe damage to the liver, kidneys and/or other organs. Recovery can take years, and long-term effects have been observed.
High Risk Groups
As with other zoonotic diseases (spread from animals to humans), the CDC explains:
Anyone can become sick from a zoonotic disease, including healthy people. However, some people may be more at risk than others and should take steps to protect themselves or family members. These people are more likely than others to get really sick, and even die, from infection with certain diseases. These groups of people include:
- Children younger than 5
- Adults older than 65
- People with weakened immune systems21
How can I protect myself and my family from zoonotic diseases like Leptospirosis?
Prevention is the key. Here are measures for minimizing your risk of exposure to Leptospira bacteria:
- Wash your hands. Whenever you come into contact with animals or their environment (petting zoo, occupational requirement, recreationally) be sure to thoroughly wash your hands with soap and water. If you use hand sanitizer, be sure to also wash your hands at your next opportunity.
- Wear protective clothing and proper footwear. Whether wading through an outdoor stream recreationally, working in higher-risk occupations, or dealing with a natural disaster situation, be aware of how your skin may come into contact with potentially contaminated sources.
- Use careful food preparation practices. Examples may include:
- Avoid raw milk, unpasteurized dairy products, and unpasteurized juices (like fresh apple cider).
- Wash raw produce (fruits and vegetables) thoroughly, especially leafy greens, which provide many crevices for bacteria to adhere to. Rinse carefully to remove dirt and bacteria. Store meat and non meat foods separately and use separate cutting boards.
- Avoid swallowing water when swimming or playing in lakes, ponds, or streams.
- Completely avoid areas where the potential for contamination is high. As mentioned previously, Hawaii posts signs to deter visitors from coming into contact with a number of waterfalls and streams. Keep this in mind.
- In developing urban areas, take steps to control rat populations, and precautionary measures during seasons of heavy rain and/or flooding.
- Always ensure your drinking water is adequately treated. Be mindful when traveling to areas with higher rates of Leptospirosis. Tap water quality and water infrastructure capabilities may vary greatly. When you must use raw sources, follow best practices to treat the water properly before consumption.
USE AN APPROPRIATE FINAL BARRIER SYSTEM FOR DAILY WATER PURIFICATION
One of the most important and concrete steps anyone can take to reduce the risk of Leptospirosis is to put an appropriate final barrier system in place to purify your family’s drinking water on a daily basis. It is important to know that Leptospira is an extremely small pathogenic bacterium. The size of most pathogenic bacteria range from .5 micron and larger. Whereas, Leptospira is a mere .2 microns in diameter. Therefore it is essential that a proper water purifier be utilized. Most water filters do not remove bacteria and among those that do, the vast majority have tested removal capabilities utilizing bacteria that are .5 microns and larger. Use purified water for all food preparation, rinsing of dishes and cookware, and daily hydration.
The Industry Leader in Gravity-Fed Water Purification
Berkey® Systems equipped with powerful Black Berkey® Purification Elements are portable, economical, and proven. Explore specific performance information for Leptospira bacteria below. For information on E. coli, another common bacteria found in raw, outdoor water sources, refer to our article, “E. coli Bacteria Explained.”
Black Berkey® Purification Element Leptospira Bacteria Reduction Test Results
The Black Berkey® Purification Elements were tested to an extreme level, with a far greater amount of Leptospira bacteria than typically found occurring in nature. So, even in a case where Leptospira bacteria may exceed typical natural levels, you know that the Black Berkey® Purification Elements will remove or greatly reduce this potential contaminant from your drinking water. Review the testing results:
LEPTOSPIRA BACTERIA TESTING FURTHER EXPLAINED
Black Berkey® Purification Elements were tested to extreme levels in order to insure that Leptospira would be greatly reduced from potentially contaminated water. The water used in testing the Black Berkey® elements was somewhere between 1,174 and 46,740 times more contaminated than naturally-occurring contamination levels.
(The concentration levels of Leptospira in the pre-filtered test water had 24,600 Colony Forming Units per 100 mL of the influent Test water. Recent testing for Leptospira in Hawaii indicated that contamination levels found in coastal streams in Hawaii ranged between 10 genomes/100 mL and 398 genomes/100 mL.22 There is an average of approximately 19 Colony Forming Units per 100 genomes. Therefore, 2,460,000 CFU’s in the pre-filtered test water would equal about 467,400 genomes per 100 mL of water.)
MORE ON THE PRECEDING DATA
To further understand the preceding data, consider the following terms:
CFU (Colony Forming Unit)– A CFU (Colony Forming Unit) is a is “…a unit used to estimate the number of viable bacteria or fungal cells in a sample.”23 Biology Online offers a more in-depth definition: “A measure of viable cells in which a colony represents an aggregate of cells derived from a single progenitor cell. Supplement. CFU is used to determine the number of viable bacterial cells in a sample per mL.“24
Genome– “In terms of modern molecular biology and genetics, a genome is the genetic material of an organism. It consists of DNA. The genome includes both the genes and the noncoding DNA, as well as the genetic material of the mitochondria and chloroplasts.”25
The Median Ratio Between CFU and Genomes
Colony Forming Units and genomes are not the same thing. Measuring one does not mean one will find exactly the same number of the other. In the testing of other bacteria contaminates (in this case S. pneumoniae), it was determined that the median ratio between the two is about 0.19. So, for every 19 colony forming units, there are approximately 100 genomes. And keep in mind, this is on the conservative side.26
SYSTEM USE IN CASES OF EXTREME BIOLOGICAL OR VIRAL CONTAMINATION
Please note, as an additional precaution, if using a source of water that you believe might contain extreme viral and bacteriological contamination such as Leptospira or E. coli bacteria, it is recommended by the CDC, EPA, and other organizations that approximately sixteen drops of plain bleach (sodium hypochlorite) or iodine per gallon be added to treat the source water before purifying. This should kill minute pathogens such as viruses, within 30 minutes. Simply add the drops to a pitcher of water, wait a half hour and then pour the treated water into the top chamber of your system. The disinfectant will be removed from the treated water entirely with the Berkey® system, including any odor or taste.
* Please use only room-temperature water with your system. Using boiling water can cause damage to the purification elements inside the Berkey® system.
** Berkey® systems always highly recommends using the cleanest source water available, whenever possible.
THE BOTTOM LINE
Berkey® Water Purification Systems address a broad universe of potential contaminants, including viruses, bacteria, pesticides, pharmaceuticals, heavy metals and even radiologicals while leaving in the healthy minerals your body needs. Confidently use your Berkey® System as a final barrier solution daily.
(1) Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses
(2) Leptospirosis: The “mysterious” mimic
(3) CDC: Zoonotic Diseases
(4) Introduction to Leptospirosis
(5) WHO: Leptospirosis
(6) CDC: Leptospirosis Infection
(6) WHO: Leptospirosis Fact Sheet
(7) CDC: Leptospirosis and Healthcare Works
(8) Risk in Hawaii
(9) Global Morbidity and Mortality of Leptospirosis: A Systematic Review
(10) WHO: Leptospirosis Fact Sheet
(11) WHO: Leptospirosis Fact Sheet
(12) CDC: Risk of Exposure
(13) Wikipedia: Leptospira
(14) Leptospirosis: a worldwide resurgent zoonosis and important cause of acute renal failure and death in developing nations.
(15) Leptospirosis: The “mysterious” mimic
(16) Laboratory diagnosis of leptospirosis: A challenge
(17) CDC: Signs and Symptoms
(18) CDC: Signs and Symptoms
(19) Leptospirosis: The “mysterious” mimic
(20) Wikipedia: Hepatorenal syndrome
(21) CDC: Zoonotic Diseases
(22) Quantitative PCR-based detection of pathogenic Leptospira in Hawai’ian coastal streams
(23) Wikipedia: Colony-forming unit
(24) Biology Online: Colony-forming unit
(25) Wikipedia: Genome
(26) Making standards for quantitative real-time pneumococcal PCR